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The recommended dose of aspirin and extended-release dipyridamole capsules is one capsule given orally twice daily, one in the morning and one in the evening.
Decisions to include these reactions in labeling are typically based on one or more of the following factors 1 seriousness of the reaction, 2 frequency of reporting, or 3 strength of causal connection to aspirin and extended-release dipyridamole.
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However, acute intravenous administration of persantine dipyridamole may worsen regional myocardial perfusion distal to partial occlusion of coronary arteries.
In studies in which apo-dipyridamole was administered in the feed to mice up to 111 weeks in males and females and rats up to 128 weeks in males and up to 142 weeks in females , there was no evidence of drug-related carcinogenesis.
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apo-dipyridamole is highly bound to plasma proteins.