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Concomitant application of methotrexate and theophylline can reduce theophylline clearance.

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Such patients require especially careful monitoring for toxicity, and require dose reduction or, in some cases, discontinuation of methotrexate administration.

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Methotrexate has immune modulatory effects.

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Read the patient information leaflet that comes with methotrexate tablets before you start using it and each time you get a refill.

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See the end of this leaflet for a complete list of ingredients in methotrexate tablets.

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Otrexup or rasuvo methotrexate injected under the skin is for use only 1 time each week.

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