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The excretion of chloroquine and the major metabolite, desethylchloroquine, in breast milk was investigated in eleven lactating mothers following a single oral dose of chloroquine 600 mg base .

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Cimetidine can inhibit the metabolism of chloroquine.increasing its plasma level. Concomitant use of cimetidine should be avoided.

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Hydroxychloroquine has largely replaced chloroquine in the United States.except among patients who travel to areas endemic with malaria. Although the mechanisms of the two agents are presumed to be the same.many reports suggest that chloroquine is more toxic to the retina than hydroxychloroquine. The toxic dosage for chloroquine was derived from hydroxychloroquine retinal toxicity studies.although no definitive data have shown pharmacologic equivalence. [1]

Store at room temperature. Store in how much is chloroquine phosphate dry place. Do not store in a bathroom. Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets. Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Chemically.it is 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino] quinoline phosphate (1.2) and has the following structural formula.

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