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Based on a population pharmacokinetic analysis.rufinamide clearance was decreased by valproate. Rufinamide concentrations were increased by.

In a study of adjunctive therapy for complex partial seizures in which patients were receiving either carbamazepine or phenytoin in addition to adjustment of carbamazepine or phenytoin dosage was needed [see Clinical Studies ]. However.since valproate may interact with these or other concurrently administered AEDs as well as other drugs.periodic plasma concentration determinations of concomitant AEDs are recommended during the early course of therapy [see DRUG INTERACTIONS ].

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