The following table summarizes the incidence of adverse reactions reported at a frequency of 2 or greater from clinical trials ingle, pritchard, buchanan which compared tamoxifen therapy to ovarian ablation in premenopausal patients with metastatic breast cancer.
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4-hydroxytamoxifen, mexiletine, and tranilast did not induce cyp1a1 in mda-mb-468 cells; moreover, in combination with tcdd, mexiletine was a potent ahr antagonist, tranilast was a partial antagonist, and 4-hydroxytamoxifen also exhibited some ahr antagonist activity.