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see agranulocytosis below see extrapyramidal side effect epse especially with high potency first generation agents and risperidone risperdal all antipsychotics can cause tardive dyskinesia neuroleptic malignant syndrome all antipsychotics can cause neuroleptic malignant syndrome most common with clozapine, but all other atypical antipsychotics have caused nms anticholinergic effects especially with low potency first generation agents and clozapine clozaril sedation especially with low potency first generation agents, clozapine clozaril , olanzapine zyprexa and quetiapine seroquel hyperprolactinemia see prolactin especially with all first generation antipsychotics and risperidone risperdal postural hypotension especially with low potency first generation antipsychotics, clozapine clozaril , quetiapine seroquel , and risperidone risperdal seizures limited to overdose and those predisposed to seizures agents lower seizure threshold most common with clozapine 3 of cases and to a much lesser extent risperidone sexual dysfunction especially with all first generation antipsychotics and risperidone risperdal myocarditis most common with clozapine and chlorpromazine most cases occur within first 4-8 weeks and mild, asymptomatic cases may occur in up to 66 on clozapine fulminant myocarditis has a high mortality 50 treated as cardiomyopathy ace inhibitors, beta blockers, diuretics ventricular arrhythmia including cardiac arrest antipsychotic agent relative risk 3.
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healthcare professionals who prescribe clozaril must be certified with the program by enrolling and completing training patients who receive clozaril must be enrolled in the program and comply with the anc testing and monitoring requirements pharmacies dispensing clozaril must be certified with the program by enrolling and completing training and must only dispense to patients who are eligible to receive clozaril.
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